KMID : 0882420070730001085
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Korean Journal of Medicine 2007 Volume.73 No. 0 p.1085 ~ p.1089
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A case of Reiter¡¯s syndrome that was treated with etanercept
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Yoo Hyun-Seung
Jo Ji-Hoon Lee Su-Ee Lee Jae-Hoon Lee Chae-Wook Lee Sung-Won Chung Won-Tae
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Abstract
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Reiter¡¯s syndrome is the combination of three symptoms: an inflammatory arthritis of large joints, inflammation of the eyes (conjunctivitis and uveitis) and urethritis. NSAIDs, steroids, antibiotics and immunosuppressive agents are used for the treatment of the Reiter¡¯s syndrome. Tumor necrosis factor-¥á (TNF-¥á), which has been linked to the immune system and inflammation, plays an important role in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). So, TNF- inhibitor is established as an important and effective therapy for both RA and AS to decrease joint pain and synovial inflammation. An elevated level of TNF-¥á has been identified in Reiter¡¯s syndrome. This finding has provided a rationale for use of TNF-¥á inhibitors in the treatment of Reiter¡¯s syndrome. We investigated a case of Reiter¡¯s syndrome in a 24-year-old male who has failed with receiving sulfasalazine, indomethacin and steroid. Yet after using a TNF-¥á inhibitor, the polyarthritis, urethritis and skin lesions improved. (Korean J Med 73:S1085-S1089, 2007)
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KEYWORD
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Reiter¡¯s syndrome, TNF-¥á inhibitor
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